Cargando…

Endothelin-1 Mediated Decrease in Mitochondrial Gene Expression and Bioenergetics Contribute to Neurodegeneration of Retinal Ganglion Cells

Endothelin-1 (ET-1) is a vasoactive peptide that is elevated in aqueous humor as well as circulation of primary open angle glaucoma (POAG) patients. ET-1 has been shown to promote degeneration of optic nerve axons and apoptosis of retinal ganglion cells (RGCs), however, the precise mechanisms are st...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chaphalkar, Renuka M., Stankowska, Dorota L., He, Shaoqing, Kodati, Bindu, Phillips, Nicole, Prah, Jude, Yang, Shaohua, Krishnamoorthy, Raghu R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046667/ https://www.ncbi.nlm.nih.gov/pubmed/32107448 http://dx.doi.org/10.1038/s41598-020-60558-6

Ejemplares similares

Involvement of c-Jun N-terminal kinase 2 (JNK2) in Endothelin-1 (ET-1) Mediated Neurodegeneration of Retinal Ganglion Cells
por: Kodati, Bindu, et al.
Publicado: (2021)

Role of mitophagy in ocular neurodegeneration
por: Brooks, Calvin D., et al.
Publicado: (2023)

Endothelin B Receptors Contribute to Retinal Ganglion Cell Loss in a Rat Model of Glaucoma
por: Minton, Alena Z., et al.
Publicado: (2012)

Systemically administered peptain-1 inhibits retinal ganglion cell death in animal models: implications for neuroprotection in glaucoma
por: Stankowska, Dorota L., et al.
Publicado: (2019)

Upregulation of the endothelin A (ET(A)) receptor and its association with neurodegeneration in a rodent model of glaucoma
por: McGrady, Nolan R., et al.
Publicado: (2017)

Correction: Systemically administered peptain-1 inhibits retinal ganglion cell death in animal models: implications for neuroprotection in glaucoma
por: Stankowska, Dorota L., et al.
Publicado: (2019)

Nanoencapsulated hybrid compound SA-2 with long-lasting intraocular pressure–lowering activity in rodent eyes
por: Stankowska, Dorota L., et al.
Publicado: (2021)

A feed-forward regulation of endothelin receptors by c-Jun in human non-pigmented ciliary epithelial cells and retinal ganglion cells
por: Wang, Junming, et al.
Publicado: (2017)

Involvement of AP-1 and C/EBPβ in Upregulation of Endothelin B (ET(B)) Receptor Expression in a Rodent Model of Glaucoma
por: He, Shaoqing, et al.
Publicado: (2013)

Oral administration of a dual ET(A)/ET(B) receptor antagonist promotes neuroprotection in a rodent model of glaucoma
por: Kodati, Bindu, et al.
Publicado: (2022)

Mitochondria-associated endoplasmic reticulum membranes (MAMs) and their role in glaucomatous retinal ganglion cell degeneration—a mini review
por: Pham, Jennifer H., et al.
Publicado: (2023)

Vascular derived endothelin receptor A controls endothelin-induced retinal ganglion cell death
por: Marola, Olivia J., et al.
Publicado: (2022)

The Role of Bioenergetics in Neurodegeneration
por: Strope, Taylor A., et al.
Publicado: (2022)

Bcl-2, Bcl-xL, and p-AKT are involved in neuroprotective effects of transcription factor Brn3b in an ocular hypertension rat model of glaucoma
por: Phatak, Nitasha R., et al.
Publicado: (2016)

Modulating mitochondrial calcium channels (TRPM2/MCU/NCX) as a therapeutic strategy for neurodegenerative disorders
por: Johnson, Gretchen A., et al.
Publicado: (2023)

Astrocyte Reactivity: A Biomarker for Retinal Ganglion Cell Health in Retinal Neurodegeneration
por: Formichella, Cathryn R, et al.
Publicado: (2014)

Endothelin 1-induced retinal ganglion cell death is largely mediated by JUN activation
por: Marola, Olivia J., et al.
Publicado: (2020)

Neuroprotection of Rodent and Human Retinal Ganglion Cells In Vitro/Ex Vivo by the Hybrid Small Molecule SA-2
por: Pham, Jennifer H., et al.
Publicado: (2022)

Peptains block retinal ganglion cell death in animal models of ocular hypertension: implications for neuroprotection in glaucoma
por: Nam, Mi-Hyun, et al.
Publicado: (2022)

AIBP protects retinal ganglion cells against neuroinflammation and mitochondrial dysfunction in glaucomatous neurodegeneration
por: Choi, Soo-Ho, et al.
Publicado: (2020)

Involvement of endothelins in neuroprotection of valosin-containing protein modulators against retinal ganglion cell damage
por: Kusaka, Mami, et al.
Publicado: (2022)

Redox Status and Bioenergetics Liaison in Cancer and Neurodegeneration
por: Filomeni, Giuseppe, et al.
Publicado: (2012)

Mitochondrial bioenergetics and neurodegeneration: a paso doble
por: Rossi, Alice, et al.
Publicado: (2020)

Long-Term Effects on Retinal Structure and Function in a Mouse Endothelin-1 Model of Retinal Ganglion Cell Degeneration
por: Lakshmanan, Yamunadevi, et al.
Publicado: (2023)

Targeting Mitochondrial Dysfunction and Oxidative Stress to Prevent the Neurodegeneration of Retinal Ganglion Cells
por: Catalani, Elisabetta, et al.
Publicado: (2023)

Kynurenic Acid Protects Against Ischemia/Reperfusion-Induced Retinal Ganglion Cell Death in Mice
por: Nahomi, Rooban B., et al.
Publicado: (2020)

Role of A-Kinase Anchoring Protein 1 in Retinal Ganglion Cells: Neurodegeneration and Neuroprotection
por: Bastola, Tonking, et al.
Publicado: (2023)

Nitric Oxide Inactivation Mechanisms in the Brain: Role in Bioenergetics and Neurodegeneration
por: Santos, Ricardo M., et al.
Publicado: (2012)

Retinal venous pressure: the role of endothelin
por: Flammer, Josef, et al.
Publicado: (2015)

Effect of Ubiquinol on Glaucomatous Neurodegeneration and Oxidative Stress: Studies for Retinal Ganglion Cell Survival and/or Visual Function
por: Edwards, Genea, et al.
Publicado: (2020)

Retinal Neurodegeneration in the Course of Diabetes-Pathogenesis and Clinical Perspective
por: Araszkiewicz, Aleksandra, et al.
Publicado: (2016)

Autophagy disruption reduces mTORC1 activation leading to retinal ganglion cell neurodegeneration associated with glaucoma
por: Huang, Kang-Chieh, et al.
Publicado: (2023)

Sigma-1R Protects Retinal Ganglion Cells in Optic Nerve Crush Model for Glaucoma
por: Li, Linya, et al.
Publicado: (2021)

ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects
por: Zhao, Yuanyuan, et al.
Publicado: (2019)

Cellular Specificity and Inter-cellular Coordination in the Brain Bioenergetic System: Implications for Aging and Neurodegeneration
por: Qi, Guoyuan, et al.
Publicado: (2020)

Acute inhibition of OGA sex-dependently alters the networks associated with bioenergetics, autophagy, and neurodegeneration
por: Huynh, Van N., et al.
Publicado: (2022)

Testosterone Decreases Placental Mitochondrial Content and Cellular Bioenergetics
por: Mishra, Jay S., et al.
Publicado: (2020)

Maprotiline restores ER homeostasis and rescues neurodegeneration via Histamine Receptor H1 inhibition in retinal ganglion cells
por: Chen, Wei, et al.
Publicado: (2022)

Effects of hydrogen sulfide on mitochondrial function and cellular bioenergetics
por: Paul, Bindu D., et al.
Publicado: (2020)

Electrically-evoked responses for retinal prostheses are differentially altered depending on ganglion cell types in outer retinal neurodegeneration caused by Crb1 gene mutation
por: Roh, Hyeonhee, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_a80k2dis17e17pfno43vensgvj