The PERK Inhibitor GSK2606414 Enhances Reovirus Infection in Head and Neck Squamous Cell Carcinoma via an ATF4-Dependent Mechanism

Reovirus type 3 Dearing (reovirus) is a tumor-selective oncolytic virus currently under evaluation in clinical trials. Here, we report that the therapeutic efficacy of reovirus in head and neck squamous cell cancer can be enhanced by targeting the unfolded protein response (UPR) kinase, protein kina...

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Detalles Bibliográficos
Autores principales: McLaughlin, Martin, Pedersen, Malin, Roulstone, Victoria, Bergerhoff, Katharina F., Smith, Henry G., Whittock, Harriet, Kyula, Joan N., Dillon, Magnus T., Pandha, Hardev S., Vile, Richard, Melcher, Alan A., Harrington, Kevin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047134/
https://www.ncbi.nlm.nih.gov/pubmed/32128359
http://dx.doi.org/10.1016/j.omto.2020.01.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047134/
https://www.ncbi.nlm.nih.gov/pubmed/32128359
http://dx.doi.org/10.1016/j.omto.2020.01.001

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