The Regulator of G Protein Signaling Homologous Domain of G Protein-Coupled Receptor Kinase 2 Mediates Short-Term Desensitization of β3-Adrenergic Receptor

G protein coupled receptor (GPCR) kinases (GRKs) are key regulators of GPCR signaling. Canonical mechanism of GPCR desensitization involves receptor phosphorylation by GRKs followed by arrestin recruitment and uncoupling from heterotrimeric G protein. Although β3-adrenergic receptor (β3AR) lacks pho...

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Detalles Bibliográficos
Autores principales: Echeverría, Emiliana, Cabrera, Maia, Burghi, Valeria, Sosa, Máximo, Ripoll, Sonia, Yaneff, Agustín, Monczor, Federico, Davio, Carlos, Shayo, Carina, Fernández, Natalia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047201/
https://www.ncbi.nlm.nih.gov/pubmed/32153413
http://dx.doi.org/10.3389/fphar.2020.00113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047201/
https://www.ncbi.nlm.nih.gov/pubmed/32153413
http://dx.doi.org/10.3389/fphar.2020.00113

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