In silico Investigations of the Mode of Action of Novel Colchicine Derivatives Targeting β-Tubulin Isotypes: A Search for a Selective and Specific β-III Tubulin Ligand

The cardinal role of microtubules in cell mitosis makes them interesting drug targets for many pharmacological treatments, including those against cancer. Moreover, different expression patterns between cell types for several tubulin isotypes represent a great opportunity to improve the selectivity...

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Detalles Bibliográficos
Autores principales: Pallante, Lorenzo, Rocca, Antonio, Klejborowska, Greta, Huczynski, Adam, Grasso, Gianvito, Tuszynski, Jack A., Deriu, Marco A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047339/
https://www.ncbi.nlm.nih.gov/pubmed/32154219
http://dx.doi.org/10.3389/fchem.2020.00108

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047339/
https://www.ncbi.nlm.nih.gov/pubmed/32154219
http://dx.doi.org/10.3389/fchem.2020.00108

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