Sphingosine-1-Phosphate Receptors Modulators Decrease Signs of Neuroinflammation and Prevent Parkinson’s Disease Symptoms in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Mouse Model

Sphingosine-1-phosphate (S1P) is a potent bioactive lipid mediator that acts as a natural ligand upon binding to five different receptors that are located in astrocytes, oligodendrocytes, microglial and neuronal cells. Recently, global activation of these receptors by FTY720 (fingolimod) has been su...

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Detalles Bibliográficos
Autores principales: Pépin, Élise, Jalinier, Tim, Lemieux, Guillaume L., Massicotte, Guy, Cyr, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047735/
https://www.ncbi.nlm.nih.gov/pubmed/32153401
http://dx.doi.org/10.3389/fphar.2020.00077

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047735/
https://www.ncbi.nlm.nih.gov/pubmed/32153401
http://dx.doi.org/10.3389/fphar.2020.00077

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