HDAC8 inhibitor attenuates airway responses to antigen stimulus through synchronously suppressing galectin-3 expression and reducing macrophage-2 polarization

BACKGROUND: This study was to investigate of the mechanism by which histone deacetylase (HDAC) 8 inhibitor ameliorated airway hyperresponsiveness (AHR) and allergic airway inflammation. METHODS: Mice were sensitized and then treated with budesonide (BUD) or PCI-34051 (PCI) prior to exposing to norma...

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Detalles Bibliográficos
Autores principales: Li, Meng-lu, Su, Xin-ming, Ren, Yuan, Zhao, Xuan, Kong, Ling-fei, Kang, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048058/
https://www.ncbi.nlm.nih.gov/pubmed/32111211
http://dx.doi.org/10.1186/s12931-020-1322-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048058/
https://www.ncbi.nlm.nih.gov/pubmed/32111211
http://dx.doi.org/10.1186/s12931-020-1322-5

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