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Plasma membrane v-ATPase controls oncogenic Ras-induced macropinocytosis

Oncogenic activation of Ras is associated with the acquisition of a unique set of metabolic dependencies that contribute to tumor cell fitness. Mutant Ras cells are endowed with the capability to internalize and degrade extracellular protein via a fluid–phase uptake mechanism termed macropinocytosis...

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Detalles Bibliográficos
Autores principales: Ramirez, Craig, Hauser, Andrew D., Vucic, Emily A., Bar-Sagi, Dafna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048194/
https://www.ncbi.nlm.nih.gov/pubmed/31827278
http://dx.doi.org/10.1038/s41586-019-1831-x