Recombinant adiponectin peptide promotes neuronal survival after intracerebral haemorrhage by suppressing mitochondrial and ATF4‐CHOP apoptosis pathways in diabetic mice via Smad3 signalling inhibition

OBJECTIVE: Low levels of adiponectin (APN), a biomarker of diabetes mellitus, have been implicated in the poor outcome of intracerebral haemorrhage (ICH). Herein, we aimed to demonstrate the neuroprotective effects of a blood‐brain barrier‐permeable APN peptide (APNp) on ICH injury in diabetic mice...

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Detalles Bibliográficos
Autores principales: Wu, Xun, Luo, Jianing, Liu, Haixiao, Cui, Wenxing, Guo, Wei, Zhao, Lei, Guo, Hao, Bai, Hao, Guo, Kang, Feng, Dayun, Qu, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048203/
https://www.ncbi.nlm.nih.gov/pubmed/31922310
http://dx.doi.org/10.1111/cpr.12759

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048203/
https://www.ncbi.nlm.nih.gov/pubmed/31922310
http://dx.doi.org/10.1111/cpr.12759

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