Cargando…
Longitudinal DNA methylation differences precede type 1 diabetes
DNA methylation may be involved in development of type 1 diabetes (T1D), but previous epigenome-wide association studies were conducted among cases with clinically diagnosed diabetes. Using multiple pre-disease peripheral blood samples on the Illumina 450 K and EPIC platforms, we investigated longit...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048736/ https://www.ncbi.nlm.nih.gov/pubmed/32111940 http://dx.doi.org/10.1038/s41598-020-60758-0 |
_version_ | 1783502321738579968 |
---|---|
author | Johnson, Randi K. Vanderlinden, Lauren A. Dong, Fran Carry, Patrick M. Seifert, Jennifer Waugh, Kathleen Shorrosh, Hanan Fingerlin, Tasha Frohnert, Brigitte I. Yang, Ivana V. Kechris, Katerina Rewers, Marian Norris, Jill M. |
author_facet | Johnson, Randi K. Vanderlinden, Lauren A. Dong, Fran Carry, Patrick M. Seifert, Jennifer Waugh, Kathleen Shorrosh, Hanan Fingerlin, Tasha Frohnert, Brigitte I. Yang, Ivana V. Kechris, Katerina Rewers, Marian Norris, Jill M. |
author_sort | Johnson, Randi K. |
collection | PubMed |
description | DNA methylation may be involved in development of type 1 diabetes (T1D), but previous epigenome-wide association studies were conducted among cases with clinically diagnosed diabetes. Using multiple pre-disease peripheral blood samples on the Illumina 450 K and EPIC platforms, we investigated longitudinal methylation differences between 87 T1D cases and 87 controls from the prospective Diabetes Autoimmunity Study in the Young (DAISY) cohort. Change in methylation with age differed between cases and controls in 10 regions. Average longitudinal methylation differed between cases and controls at two genomic positions and 28 regions. Some methylation differences were detectable and consistent as early as birth, including before and after the onset of preclinical islet autoimmunity. Results map to transcription factors, other protein coding genes, and non-coding regions of the genome with regulatory potential. The identification of methylation differences that predate islet autoimmunity and clinical diagnosis may suggest a role for epigenetics in T1D pathogenesis; however, functional validation is warranted. |
format | Online Article Text |
id | pubmed-7048736 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-70487362020-03-05 Longitudinal DNA methylation differences precede type 1 diabetes Johnson, Randi K. Vanderlinden, Lauren A. Dong, Fran Carry, Patrick M. Seifert, Jennifer Waugh, Kathleen Shorrosh, Hanan Fingerlin, Tasha Frohnert, Brigitte I. Yang, Ivana V. Kechris, Katerina Rewers, Marian Norris, Jill M. Sci Rep Article DNA methylation may be involved in development of type 1 diabetes (T1D), but previous epigenome-wide association studies were conducted among cases with clinically diagnosed diabetes. Using multiple pre-disease peripheral blood samples on the Illumina 450 K and EPIC platforms, we investigated longitudinal methylation differences between 87 T1D cases and 87 controls from the prospective Diabetes Autoimmunity Study in the Young (DAISY) cohort. Change in methylation with age differed between cases and controls in 10 regions. Average longitudinal methylation differed between cases and controls at two genomic positions and 28 regions. Some methylation differences were detectable and consistent as early as birth, including before and after the onset of preclinical islet autoimmunity. Results map to transcription factors, other protein coding genes, and non-coding regions of the genome with regulatory potential. The identification of methylation differences that predate islet autoimmunity and clinical diagnosis may suggest a role for epigenetics in T1D pathogenesis; however, functional validation is warranted. Nature Publishing Group UK 2020-02-28 /pmc/articles/PMC7048736/ /pubmed/32111940 http://dx.doi.org/10.1038/s41598-020-60758-0 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Johnson, Randi K. Vanderlinden, Lauren A. Dong, Fran Carry, Patrick M. Seifert, Jennifer Waugh, Kathleen Shorrosh, Hanan Fingerlin, Tasha Frohnert, Brigitte I. Yang, Ivana V. Kechris, Katerina Rewers, Marian Norris, Jill M. Longitudinal DNA methylation differences precede type 1 diabetes |
title | Longitudinal DNA methylation differences precede type 1 diabetes |
title_full | Longitudinal DNA methylation differences precede type 1 diabetes |
title_fullStr | Longitudinal DNA methylation differences precede type 1 diabetes |
title_full_unstemmed | Longitudinal DNA methylation differences precede type 1 diabetes |
title_short | Longitudinal DNA methylation differences precede type 1 diabetes |
title_sort | longitudinal dna methylation differences precede type 1 diabetes |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048736/ https://www.ncbi.nlm.nih.gov/pubmed/32111940 http://dx.doi.org/10.1038/s41598-020-60758-0 |
work_keys_str_mv | AT johnsonrandik longitudinaldnamethylationdifferencesprecedetype1diabetes AT vanderlindenlaurena longitudinaldnamethylationdifferencesprecedetype1diabetes AT dongfran longitudinaldnamethylationdifferencesprecedetype1diabetes AT carrypatrickm longitudinaldnamethylationdifferencesprecedetype1diabetes AT seifertjennifer longitudinaldnamethylationdifferencesprecedetype1diabetes AT waughkathleen longitudinaldnamethylationdifferencesprecedetype1diabetes AT shorroshhanan longitudinaldnamethylationdifferencesprecedetype1diabetes AT fingerlintasha longitudinaldnamethylationdifferencesprecedetype1diabetes AT frohnertbrigittei longitudinaldnamethylationdifferencesprecedetype1diabetes AT yangivanav longitudinaldnamethylationdifferencesprecedetype1diabetes AT kechriskaterina longitudinaldnamethylationdifferencesprecedetype1diabetes AT rewersmarian longitudinaldnamethylationdifferencesprecedetype1diabetes AT norrisjillm longitudinaldnamethylationdifferencesprecedetype1diabetes |