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Antibody transcytosis across brain endothelial-like cells occurs nonspecifically and independent of FcRn
The blood-brain barrier (BBB) hinders the brain delivery of therapeutic immunoglobulin γ (IgG) antibodies. Evidence suggests that IgG-specific processing occurs within the endothelium of the BBB, but any influence on transcytosis remains unclear. Here, involvement of the neonatal Fc receptor (FcRn),...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048754/ https://www.ncbi.nlm.nih.gov/pubmed/32111886 http://dx.doi.org/10.1038/s41598-020-60438-z |