Cryo-EM structures of the XPF-ERCC1 endonuclease reveal how DNA-junction engagement disrupts an auto-inhibited conformation

The structure-specific endonuclease XPF-ERCC1 participates in multiple DNA damage repair pathways including nucleotide excision repair (NER) and inter-strand crosslink repair (ICLR). How XPF-ERCC1 is catalytically activated by DNA junction substrates is not currently understood. Here we report cryo-...

Descripción completa

Detalles Bibliográficos
Autores principales: Jones, Morgan, Beuron, Fabienne, Borg, Aaron, Nans, Andrea, Earl, Christopher P., Briggs, David C., Snijders, Ambrosius P., Bowles, Maureen, Morris, Edward P., Linch, Mark, McDonald, Neil Q.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048804/
https://www.ncbi.nlm.nih.gov/pubmed/32111838
http://dx.doi.org/10.1038/s41467-020-14856-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048804/
https://www.ncbi.nlm.nih.gov/pubmed/32111838
http://dx.doi.org/10.1038/s41467-020-14856-2

Ejemplares similares