Pharmacological LRH-1/Nr5a2 inhibition limits pro-inflammatory cytokine production in macrophages and associated experimental hepatitis

Liver receptor homolog-1 (LRH-1, Nr5a2) is an orphan nuclear receptor mainly expressed in tissues of endodermal origin, where its physiological role has been extensively studied. LRH-1 has been implicated in liver cell differentiation and proliferation, as well as glucose, lipid, and bile acid metab...

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Detalles Bibliográficos
Autores principales: Schwaderer, Juliane, Phan, Truong San, Glöckner, Astrid, Delp, Johannes, Leist, Marcel, Brunner, Thomas, Delgado, M. Eugenia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048823/
https://www.ncbi.nlm.nih.gov/pubmed/32111818
http://dx.doi.org/10.1038/s41419-020-2348-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048823/
https://www.ncbi.nlm.nih.gov/pubmed/32111818
http://dx.doi.org/10.1038/s41419-020-2348-9

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