Insight into DNA substrate specificity of PARP1-catalysed DNA poly(ADP-ribosyl)ation

DNA-dependent poly(ADP-ribose) polymerases (PARPs) PARP1, PARP2 and PARP3 act as DNA break sensors signalling DNA damage. Upon detecting DNA damage, these PARPs use nicotine adenine dinucleotide as a substrate to synthesise a monomer or polymer of ADP-ribose (MAR or PAR, respectively) covalently att...

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Detalles Bibliográficos
Autores principales: Matta, Elie, Kiribayeva, Assel, Khassenov, Bekbolat, Matkarimov, Bakhyt T., Ishchenko, Alexander A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048826/
https://www.ncbi.nlm.nih.gov/pubmed/32111879
http://dx.doi.org/10.1038/s41598-020-60631-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048826/
https://www.ncbi.nlm.nih.gov/pubmed/32111879
http://dx.doi.org/10.1038/s41598-020-60631-0

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