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Insight into DNA substrate specificity of PARP1-catalysed DNA poly(ADP-ribosyl)ation
DNA-dependent poly(ADP-ribose) polymerases (PARPs) PARP1, PARP2 and PARP3 act as DNA break sensors signalling DNA damage. Upon detecting DNA damage, these PARPs use nicotine adenine dinucleotide as a substrate to synthesise a monomer or polymer of ADP-ribose (MAR or PAR, respectively) covalently att...
Autores principales: | Matta, Elie, Kiribayeva, Assel, Khassenov, Bekbolat, Matkarimov, Bakhyt T., Ishchenko, Alexander A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048826/ https://www.ncbi.nlm.nih.gov/pubmed/32111879 http://dx.doi.org/10.1038/s41598-020-60631-0 |
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