Amylin and pramlintide modulate γ-secretase level and APP processing in lipid rafts

A major characteristic of Alzheimer’s disease (AD) is the accumulation of misfolded amyloid-β (Aβ) peptide. Several studies linked AD with type 2 diabetes due to similarities between Aβ and human amylin. This study investigates the effect of amylin and pramlintide on Aβ pathogenesis and the predispo...

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Detalles Bibliográficos
Autores principales: Mousa, Youssef M., Abdallah, Ihab M., Hwang, Misako, Martin, Douglas R., Kaddoumi, Amal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048857/
https://www.ncbi.nlm.nih.gov/pubmed/32111883
http://dx.doi.org/10.1038/s41598-020-60664-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048857/
https://www.ncbi.nlm.nih.gov/pubmed/32111883
http://dx.doi.org/10.1038/s41598-020-60664-5

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