PI3K inhibitor treatment ameliorates the glucocorticoid insensitivity of PBMCs in severe asthma

BACKGROUND: Glucocorticoid (GC) insensitivity is an important feature of severe and fatal asthma. Oxidative stress can induce phosphoinositide-3-kinase (PI3K) activation, contributing to the development of GC insensitivity in chronic airway diseases. However, the underlying molecular mechanism of PI...

Descripción completa

Detalles Bibliográficos
Autores principales: Bi, Jing, Min, Zhihui, Yuan, Honglei, Jiang, Zhilong, Mao, Ruolin, Zhu, Tao, Liu, Chunfang, Zeng, Yuzhen, Song, Juan, Du, Chunling, Chen, Zhihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048898/
https://www.ncbi.nlm.nih.gov/pubmed/32112175
http://dx.doi.org/10.1186/s40169-020-0262-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048898/
https://www.ncbi.nlm.nih.gov/pubmed/32112175
http://dx.doi.org/10.1186/s40169-020-0262-5

Ejemplares similares