Role for ribosome-associated quality control in sampling proteins for MHC class I-mediated antigen presentation

Mammalian cells present a fingerprint of their proteome to the adaptive immune system through the display of endogenous peptides on MHC-I complexes. MHC-I−bound peptides originate from protein degradation by the proteasome, suggesting that stably folded, long-lived proteins could evade monitoring. H...

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Detalles Bibliográficos
Autores principales: Trentini, Débora Broch, Pecoraro, Matteo, Tiwary, Shivani, Cox, Jürgen, Mann, Matthias, Hipp, Mark S., Hartl, F. Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049129/
https://www.ncbi.nlm.nih.gov/pubmed/32047030
http://dx.doi.org/10.1073/pnas.1914401117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049129/
https://www.ncbi.nlm.nih.gov/pubmed/32047030
http://dx.doi.org/10.1073/pnas.1914401117

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