Underestimated effect of intragenic HIV-1 DNA methylation on viral transcription in infected individuals

BACKGROUND: The HIV-1 proviral genome harbors multiple CpG islands (CpGIs), both in the promoter and intragenic regions. DNA methylation in the promoter region has been shown to be heavily involved in HIV-1 latency regulation in cultured cells. However, its exact role in proviral transcriptional reg...

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Detalles Bibliográficos
Autores principales: Kint, Sam, Trypsteen, Wim, De Spiegelaere, Ward, Malatinkova, Eva, Kinloch-de Loes, Sabine, De Meyer, Tim, Van Criekinge, Wim, Vandekerckhove, Linos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049218/
https://www.ncbi.nlm.nih.gov/pubmed/32111236
http://dx.doi.org/10.1186/s13148-020-00829-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049218/
https://www.ncbi.nlm.nih.gov/pubmed/32111236
http://dx.doi.org/10.1186/s13148-020-00829-1

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