Contribution of Trough Concentration Data in the Evaluation of Multiple-Dose Pharmacokinetics for Drugs with Delayed Distributional Equilibrium and Long Half-Life

PURPOSE: The performance of “trough sampling before reaching steady-state” and “serial sampling beyond the interval between steady-state” in a multiple-dose pharmacokinetic evaluation was compared. Drugs with long half-lives, following multi-compartment pharmacokinetics, and whose distribution-relat...

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Detalles Bibliográficos
Autores principales: Choi, Suein, Jeon, Sangil, Yim, Dong-Seok, Han, Seunghoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049277/
https://www.ncbi.nlm.nih.gov/pubmed/32158198
http://dx.doi.org/10.2147/DDDT.S236701

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049277/
https://www.ncbi.nlm.nih.gov/pubmed/32158198
http://dx.doi.org/10.2147/DDDT.S236701

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