Human BCR/ABL1 induces chronic myeloid leukemia-like disease in zebrafish

Chronic myeloid leukemia (CML) is induced by the BCR/ABL1 oncogene, which encodes a protein tyrosine kinase. We examined the effect of direct overexpression of the human p210(BCR/ABL1) oncoprotein in zebrafish. Humanized p210(BCR/ABL1) protein was detectable in Tg(hsp70: p210(BCR/ABL1)) transgenic z...

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Detalles Bibliográficos
Autores principales: Xu, Mengchang, Ye, Yin, Ye, Zhi’an, Xu, Song’en, Liu, Wei, Xu, Jin, Zhang, Yiyue, Liu, Qifa, Huang, Zhibin, Zhang, Wenqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049331/
https://www.ncbi.nlm.nih.gov/pubmed/31289206
http://dx.doi.org/10.3324/haematol.2019.215939

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049331/
https://www.ncbi.nlm.nih.gov/pubmed/31289206
http://dx.doi.org/10.3324/haematol.2019.215939

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