Dynamics of strand slippage in DNA hairpins formed by CAG repeats: roles of sequence parity and trinucleotide interrupts

DNA trinucleotide repeats (TRs) can exhibit dynamic expansions by integer numbers of trinucleotides that lead to neurodegenerative disorders. Strand slipped hairpins during DNA replication, repair and/or recombination may contribute to TR expansion. Here, we combine single-molecule FRET experiments...

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Detalles Bibliográficos
Autores principales: Xu, Pengning, Pan, Feng, Roland, Christopher, Sagui, Celeste, Weninger, Keith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049705/
https://www.ncbi.nlm.nih.gov/pubmed/31974547
http://dx.doi.org/10.1093/nar/gkaa036

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049705/
https://www.ncbi.nlm.nih.gov/pubmed/31974547
http://dx.doi.org/10.1093/nar/gkaa036

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