The internal loops in the lower stem of primary microRNA transcripts facilitate single cleavage of human Microprocessor

The human Microprocessor complex cleaves primary microRNA (miRNA) transcripts (pri-miRNAs) to initiate miRNA synthesis. Microprocessor consists of DROSHA (an RNase III enzyme), and DGCR8. DROSHA contains two RNase III domains, RIIIDa and RIIIDb, which simultaneously cleave the 3p- and 5p-strands of...

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Detalles Bibliográficos
Autores principales: Nguyen, Thuy Linh, Nguyen, Trung Duc, Bao, Sheng, Li, Shaohua, Nguyen, Tuan Anh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049713/
https://www.ncbi.nlm.nih.gov/pubmed/31956890
http://dx.doi.org/10.1093/nar/gkaa018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049713/
https://www.ncbi.nlm.nih.gov/pubmed/31956890
http://dx.doi.org/10.1093/nar/gkaa018

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