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Measuring significant changes in chromatin conformation with ACCOST
Chromatin conformation assays such as Hi-C cannot directly measure differences in 3D architecture between cell types or cell states. For this purpose, two or more Hi-C experiments must be carried out, but direct comparison of the resulting Hi-C matrices is confounded by several features of Hi-C data...
Autores principales: | Cook, Kate B, Hristov, Borislav H, Le Roch, Karine G, Vert, Jean Philippe, Noble, William Stafford |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049724/ https://www.ncbi.nlm.nih.gov/pubmed/32034421 http://dx.doi.org/10.1093/nar/gkaa069 |
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