Artificial escape from XCI by DNA methylation editing of the CDKL5 gene

A significant number of X-linked genes escape from X chromosome inactivation and are associated with a distinct epigenetic signature. One epigenetic modification that strongly correlates with X-escape is reduced DNA methylation in promoter regions. Here, we created an artificial escape by editing DN...

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Detalles Bibliográficos
Autores principales: Halmai, Julian A N M, Deng, Peter, Gonzalez, Casiana E, Coggins, Nicole B, Cameron, David, Carter, Jasmine L, Buchanan, Fiona K B, Waldo, Jennifer J, Lock, Samantha R, Anderson, Johnathon D, O’Geen, Henriette, Segal, David J, Nolta, Jan, Fink, Kyle D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049732/
https://www.ncbi.nlm.nih.gov/pubmed/31925439
http://dx.doi.org/10.1093/nar/gkz1214

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049732/
https://www.ncbi.nlm.nih.gov/pubmed/31925439
http://dx.doi.org/10.1093/nar/gkz1214

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