High Glucose Downregulates Connexin 43 Expression and Its Gap Junction and Hemichannel Function in Osteocyte-like MLO-Y4 Cells Through Activation of the p38MAPK/ERK Signal Pathway

PURPOSE: Osteocyte network structure correlates with bone material quality. This network is profoundly altered in diabetic mice; however, the underlying mechanisms are unknown. The gap junction protein connexin 43 (Cx43) is necessary for normal osteocyte function and osteocyte network formation. Her...

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Detalles Bibliográficos
Autores principales: Yang, Lei, Zhou, Guangping, Li, Mingyang, Li, Yan, Yang, Liqing, Fu, Qin, Tian, Ye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049751/
https://www.ncbi.nlm.nih.gov/pubmed/32161481
http://dx.doi.org/10.2147/DMSO.S239892

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049751/
https://www.ncbi.nlm.nih.gov/pubmed/32161481
http://dx.doi.org/10.2147/DMSO.S239892

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