High-Throughput Drug Screening Identifies a Potent Wnt Inhibitor that Promotes Airway Basal Stem Cell Homeostasis

Mechanisms underpinning airway epithelial homeostatic maintenance and ways to prevent its dysregulation remain elusive. Herein, we identify that β-catenin phosphorylated at Y489 (p-β-catenin(Y489)) emerges during human squamous lung cancer progression. This led us to develop a model of airway basal...

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Detalles Bibliográficos
Autores principales: Aros, Cody J., Paul, Manash K., Pantoja, Carla J., Bisht, Bharti, Meneses, Luisa K., Vijayaraj, Preethi, Sandlin, Jenna M., France, Bryan, Tse, Jonathan A., Chen, Michelle W., Shia, David W., Rickabaugh, Tammy M., Damoiseaux, Robert, Gomperts, Brigitte N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050206/
https://www.ncbi.nlm.nih.gov/pubmed/32075752
http://dx.doi.org/10.1016/j.celrep.2020.01.059

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050206/
https://www.ncbi.nlm.nih.gov/pubmed/32075752
http://dx.doi.org/10.1016/j.celrep.2020.01.059

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