Recurrent SRSF2 mutations in MDS affect both splicing and NMD

Oncogenic mutations in the RNA splicing factors SRSF2, SF3B1, and U2AF1 are the most frequent class of mutations in myelodysplastic syndromes and are also common in clonal hematopoiesis, acute myeloid leukemia, chronic lymphocytic leukemia, and a variety of solid tumors. They cause genome-wide splic...

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Detalles Bibliográficos
Autores principales: Rahman, Mohammad Alinoor, Lin, Kuan-Ting, Bradley, Robert K., Abdel-Wahab, Omar, Krainer, Adrian R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050488/
https://www.ncbi.nlm.nih.gov/pubmed/32001512
http://dx.doi.org/10.1101/gad.332270.119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050488/
https://www.ncbi.nlm.nih.gov/pubmed/32001512
http://dx.doi.org/10.1101/gad.332270.119

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