Prediction of Passive Membrane Permeability by Semi‐Empirical Method Considering Viscous and Inertial Resistances and Different Rates of Conformational Change and Diffusion

Membrane permeability is an important property of drugs in adsorption. Many prediction methods work well for small molecules, but the prediction of middle‐molecule permeability is still difficult. In the present study, we modified a classical permeability model based on Fick's law to study pass...

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Detalles Bibliográficos
Autores principales: Fukunishi, Yoshifumi, Mashimo, Tadaaki, Kurosawa, Takashi, Wakabayashi, Yoshinori, Nakamura, Hironori K., Takeuchi, Koh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050510/
https://www.ncbi.nlm.nih.gov/pubmed/31609549
http://dx.doi.org/10.1002/minf.201900071

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050510/
https://www.ncbi.nlm.nih.gov/pubmed/31609549
http://dx.doi.org/10.1002/minf.201900071

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