Synthesis, Evaluation and Proposed Binding Pose of Substituted Spiro‐Oxindole Dihydroquinazolinones as IRAP Inhibitors

Insulin‐regulated aminopeptidase (IRAP) is a new potential macromolecular target for drugs aimed for treatment of cognitive disorders. Inhibition of IRAP by angiotensin IV (Ang IV) improves the memory and learning in rats. The majority of the known IRAP inhibitors are peptidic in character and suffe...

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Detalles Bibliográficos
Autores principales: Engen, Karin, Vanga, Sudarsana Reddy, Lundbäck, Thomas, Agalo, Faith, Konda, Vivek, Jensen, Annika Jenmalm, Åqvist, Johan, Gutiérrez‐de‐Terán, Hugo, Hallberg, Mathias, Larhed, Mats, Rosenström, Ulrika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050655/
https://www.ncbi.nlm.nih.gov/pubmed/32154052
http://dx.doi.org/10.1002/open.201900344

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050655/
https://www.ncbi.nlm.nih.gov/pubmed/32154052
http://dx.doi.org/10.1002/open.201900344

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