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Equiprobable discrete models of site-specific substitution rates underestimate the extent of rate variability
It is standard practice to model site-to-site variability of substitution rates by discretizing a continuous distribution into a small number, K, of equiprobable rate categories. We demonstrate that the variance of this discretized distribution has an upper bound determined solely by the choice of K...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7051046/ https://www.ncbi.nlm.nih.gov/pubmed/32119689 http://dx.doi.org/10.1371/journal.pone.0229493 |