Equiprobable discrete models of site-specific substitution rates underestimate the extent of rate variability

It is standard practice to model site-to-site variability of substitution rates by discretizing a continuous distribution into a small number, K, of equiprobable rate categories. We demonstrate that the variance of this discretized distribution has an upper bound determined solely by the choice of K...

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Detalles Bibliográficos
Autores principales: Mannino, Frank, Wisotsky, Sadie, Kosakovsky Pond, Sergei L., Muse, Spencer V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7051046/
https://www.ncbi.nlm.nih.gov/pubmed/32119689
http://dx.doi.org/10.1371/journal.pone.0229493

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7051046/
https://www.ncbi.nlm.nih.gov/pubmed/32119689
http://dx.doi.org/10.1371/journal.pone.0229493

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