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Functions of Conserved Domains of Human Polynucleotide Phosphorylase on RNA Oxidation

Human polynucleotide phosphorylase (hPNPase), an exoribonuclease that is primarily localized in mitochondria, plays an important role in reducing oxidized RNA and protecting cells under oxidative stress conditions. hPNPase contains two catalytic domains (RPH1 and RPH2) and two RNA binding domains (K...

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Detalles Bibliográficos
Autores principales: Malla, Sulochan, Li, Zhongwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7051052/
https://www.ncbi.nlm.nih.gov/pubmed/32123871
http://dx.doi.org/10.36959/584/448