Voluntary wheel running has no impact on brain and liver mitochondrial DNA copy number or mutation measures in the PolG mouse model of aging

The mitochondrial theory of aging attributes much of the aging process to mitochondrial DNA damage. The polymerase gamma (PolG) mutant mouse was designed to evaluate this theory and thus carries a mutated proofreading region of polymerase gamma (D257A) that exclusively transcribes the mitochondrial...

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Detalles Bibliográficos
Autores principales: Maclaine, Kendra D., Stebbings, Kevin A., Llano, Daniel A., Rhodes, Justin S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7051064/
https://www.ncbi.nlm.nih.gov/pubmed/32119683
http://dx.doi.org/10.1371/journal.pone.0226860

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7051064/
https://www.ncbi.nlm.nih.gov/pubmed/32119683
http://dx.doi.org/10.1371/journal.pone.0226860

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