Cargando…

Voluntary wheel running has no impact on brain and liver mitochondrial DNA copy number or mutation measures in the PolG mouse model of aging

The mitochondrial theory of aging attributes much of the aging process to mitochondrial DNA damage. The polymerase gamma (PolG) mutant mouse was designed to evaluate this theory and thus carries a mutated proofreading region of polymerase gamma (D257A) that exclusively transcribes the mitochondrial...

Descripción completa

Detalles Bibliográficos
Autores principales:	Maclaine, Kendra D., Stebbings, Kevin A., Llano, Daniel A., Rhodes, Justin S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7051064/ https://www.ncbi.nlm.nih.gov/pubmed/32119683 http://dx.doi.org/10.1371/journal.pone.0226860

Ejemplares similares

The mtDNA mutation spectrum in the PolG mutator mouse reveals germline and somatic selection
por: Maclaine, Kendra D., et al.
Publicado: (2021)

Voluntary Wheel Running Reverses Age-Induced Changes in Hippocampal Gene Expression
por: Kohman, Rachel A., et al.
Publicado: (2011)

PolG Inhibits Gastric Cancer Glycolysis and Viability by Suppressing PKM2 Phosphorylation
por: Lv, Mengzhu, et al.
Publicado: (2021)

Voluntary wheel running: patterns and physiological effects in mice
por: Manzanares, G., et al.
Publicado: (2018)

Brain region-dependent gene networks associated with selective breeding for increased voluntary wheel-running behavior
por: Zhang, Pan, et al.
Publicado: (2018)

Voluntary wheel running delays brain atrophy in aged mice
por: Lin, Lan, et al.
Publicado: (2019)

The effect of voluntary wheel running on the antioxidant status is dependent on sociability conditions
por: Cunha, Mauricio P., et al.
Publicado: (2020)

Effects of Voluntary Running Wheel Exercise-Induced Extracellular Vesicles on Anxiety
por: Yoon, Kyeong Jin, et al.
Publicado: (2021)

Potential toxicity of quercetin: The repression of mitochondrial copy number via decreased POLG expression and excessive TFAM expression in irradiated murine bone marrow
por: Chen, Ruiqing, et al.
Publicado: (2014)

Effects of acute voluntary loaded wheel running on BDNF expression in the rat hippocampus
por: Lee, Minchul, et al.
Publicado: (2017)

Voluntary wheel running complements microdystrophin gene therapy to improve muscle function in mdx mice
por: Hamm, Shelby E., et al.
Publicado: (2021)

Voluntary wheel running complements microdystrophin gene therapy to improve muscle function in mdx mice
por: Hamm, Shelby E., et al.
Publicado: (2021)

Effects of diet-induced obesity and voluntary wheel running on the microstructure of the murine distal femur
por: Ma, Hongqiang, et al.
Publicado: (2011)

Neurogenic Processes Are Induced by Very Short Periods of Voluntary Wheel-Running in Male Mice
por: Gremmelspacher, Teresa, et al.
Publicado: (2017)

Voluntary wheel running promotes myelination in the motor cortex through Wnt signaling in mice
por: Zheng, Jian, et al.
Publicado: (2019)

Simultaneous assessment of spontaneous cage activity and voluntary wheel running in group-housed mice
por: Reuser, Annika, et al.
Publicado: (2022)

Effects of Voluntary Wheel Running Exercise on Chemotherapy-Impaired Cognitive and Motor Performance in Mice
por: Lee, Thomas H., et al.
Publicado: (2023)

Impaired Voluntary Wheel Running Behavior in the Unilateral 6-Hydroxydopamine Rat Model of Parkinson's Disease
por: Pan, Qi, et al.
Publicado: (2015)

Effects of Voluntary Wheel-Running Types on Hippocampal Neurogenesis and Spatial Cognition in Middle-Aged Mice
por: Huang, Yi-Qing, et al.
Publicado: (2018)

Voluntary wheel-running activities ameliorate depressive-like behaviors in mouse dry eye models
por: Nakano, Katsuya, et al.
Publicado: (2022)

BODY WEIGHT INFLUENCES MUSCULOSKELETAL ADAPTATION TO LONG-TERM VOLUNTARY WHEEL RUNNING DURING AGING
por: Kitase, Yukiko, et al.
Publicado: (2022)

Molecular and metabolomic effects of voluntary running wheel activity on skeletal muscle in late middle-aged rats
por: Garvey, Sean M, et al.
Publicado: (2015)

Effect of Voluntary Wheel Running on Striatal Dopamine Level and Neurocognitive Behaviors after Molar Loss in Rats
por: Zhang, Linlin, et al.
Publicado: (2017)

Voluntary Wheel Running Does Not Alter Mortality to or Immunogenicity of Vaccinia Virus in Mice: A Pilot Study
por: Pence, Brandt D., et al.
Publicado: (2018)

Voluntary wheel running behaviour as a tool to assess the severity in a mouse pancreatic cancer model
por: Weegh, Nora, et al.
Publicado: (2021)

Publisher Correction: Simultaneous assessment of spontaneous cage activity and voluntary wheel running in group-housed mice
por: Reuser, Annika, et al.
Publicado: (2022)

Voluntary Wheel Running Reduces Vesicle Development in an Endometriosis Animal Model Through Modulation of Immune Parameters
por: Appleyard, Caroline B., et al.
Publicado: (2022)

Sex-specific effects of voluntary wheel running on behavior and the gut microbiota-immune-brain axis in mice
por: Williams, Zoë A.P., et al.
Publicado: (2023)

A convolutional neural network to characterize mouse hindlimb foot strikes during voluntary wheel running
por: Huber, Phillipe, et al.
Publicado: (2023)

Interplay between Learning and Voluntary Wheel Running in Male C57BL/6NCrl Mice
por: Niiranen, Laura, et al.
Publicado: (2023)

Wheel running in the wild
por: Meijer, Johanna H., et al.
Publicado: (2014)

Voluntary wheel running in dystrophin-deficient (mdx) mice: Relationships between exercise parameters and exacerbation of the dystrophic phenotype
por: Smythe, Gayle M, et al.
Publicado: (2012)

Voluntary wheel running in mice increases the rate of neurogenesis without affecting anxiety-related behaviour in single tests
por: Garrett, Lillian, et al.
Publicado: (2012)

Effect of Long-Term Voluntary Exercise Wheel Running on Susceptibility to Bacterial Pulmonary Infections in a Mouse Model
por: van de Weert – van Leeuwen, Pauline B., et al.
Publicado: (2013)

High Fat High Sugar Diet Reduces Voluntary Wheel Running in Mice Independent of Sex Hormone Involvement
por: Vellers, Heather L., et al.
Publicado: (2017)

Effect of Voluntary Wheel-Running Exercise on the Endocrine and Inflammatory Response to Social Stress: Conditioned Rewarding Effects of Cocaine
por: Ferrer-Pérez, Carmen, et al.
Publicado: (2022)

Voluntary wheel running alters markers of amyloid-beta precursor protein processing in an ovarian hormone depleted model
por: Mohammad, Ahmad, et al.
Publicado: (2022)

Body weight influences musculoskeletal adaptation to long-term voluntary wheel running during aging in female mice
por: Kitase, Yukiko, et al.
Publicado: (2022)

Voluntary wheel running mitigates disease in an Orai1 gain-of-function mouse model of tubular aggregate myopathy
por: O’Connor, Thomas N., et al.
Publicado: (2023)

Maternal voluntary wheel running modulates glucose homeostasis, the gut microbiota and its derived fecal metabolites in offspring
por: Zhang, Ling, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_pnstgd6i3v0l3rt3mr1drcq7os