Emerging role of Fatty acid synthase in tumor initiation: implications for cancer prevention

Targeting metabolic reprogramming has emerged as a promising strategy for therapeutic intervention in cancer. We identify that fatty acid synthase (FASN) is essential for cancer initiation playing a critical role in acquiring three-dimensional (3D) growth properties during transformation. In vivo in...

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Autores principales: Bueno, Maria J., Quintela-Fandino, Miguel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7051128/
https://www.ncbi.nlm.nih.gov/pubmed/32158923
http://dx.doi.org/10.1080/23723556.2019.1709389
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author Bueno, Maria J.
Quintela-Fandino, Miguel
author_facet Bueno, Maria J.
Quintela-Fandino, Miguel
author_sort Bueno, Maria J.
collection PubMed
description Targeting metabolic reprogramming has emerged as a promising strategy for therapeutic intervention in cancer. We identify that fatty acid synthase (FASN) is essential for cancer initiation playing a critical role in acquiring three-dimensional (3D) growth properties during transformation. In vivo inhibition of FASN before oncogenic activation prevents tumor development and invasive growth suggesting that FASN could be a potential target for cancer prevention.
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spelling pubmed-70511282020-09-28 Emerging role of Fatty acid synthase in tumor initiation: implications for cancer prevention Bueno, Maria J. Quintela-Fandino, Miguel Mol Cell Oncol Author's Views Targeting metabolic reprogramming has emerged as a promising strategy for therapeutic intervention in cancer. We identify that fatty acid synthase (FASN) is essential for cancer initiation playing a critical role in acquiring three-dimensional (3D) growth properties during transformation. In vivo inhibition of FASN before oncogenic activation prevents tumor development and invasive growth suggesting that FASN could be a potential target for cancer prevention. Taylor & Francis 2020-01-20 /pmc/articles/PMC7051128/ /pubmed/32158923 http://dx.doi.org/10.1080/23723556.2019.1709389 Text en © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author's Views
Bueno, Maria J.
Quintela-Fandino, Miguel
Emerging role of Fatty acid synthase in tumor initiation: implications for cancer prevention
title Emerging role of Fatty acid synthase in tumor initiation: implications for cancer prevention
title_full Emerging role of Fatty acid synthase in tumor initiation: implications for cancer prevention
title_fullStr Emerging role of Fatty acid synthase in tumor initiation: implications for cancer prevention
title_full_unstemmed Emerging role of Fatty acid synthase in tumor initiation: implications for cancer prevention
title_short Emerging role of Fatty acid synthase in tumor initiation: implications for cancer prevention
title_sort emerging role of fatty acid synthase in tumor initiation: implications for cancer prevention
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7051128/
https://www.ncbi.nlm.nih.gov/pubmed/32158923
http://dx.doi.org/10.1080/23723556.2019.1709389
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