Hybridization capture-based next generation sequencing reliably detects FLT3 mutations and classifies FLT3-internal tandem duplication allelic ratio in acute myeloid leukemia: a comparative study to standard fragment analysis

FLT3-internal tandem duplication occurs in 20–30% of acute myeloid leukemia and confers an adverse prognosis with its allelic ratio being a key risk stratifier. The US Food and Drug Administration recently approved FLT3 inhibitors midostaurin and gilteritinib in FLT3 mutation-positive acute myeloid...

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Detalles Bibliográficos
Autores principales: He, Rong, Devine, Daniel J., Tu, Zheng Jin, Mai, Ming, Chen, Dong, Nguyen, Phuong L., Oliveira, Jennifer L., Hoyer, James D., Reichard, Kaaren K., Ollila, Paul L., Al-Kali, Aref, Tefferi, Ayalew, Begna, Kebede H., Patnaik, Mrinal M., Alkhateeb, Hassan, Viswanatha, David S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7051912/
https://www.ncbi.nlm.nih.gov/pubmed/31471587
http://dx.doi.org/10.1038/s41379-019-0359-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7051912/
https://www.ncbi.nlm.nih.gov/pubmed/31471587
http://dx.doi.org/10.1038/s41379-019-0359-9

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