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Applying switchable Cas9 variants to in vivo gene editing for therapeutic applications
Progress in targeted gene editing by programmable endonucleases has paved the way for their use in gene therapy. Particularly, Cas9 is an endonuclease with high activity and flexibility, rendering it an attractive option for therapeutic applications in clinical settings. Many disease-causing mutatio...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Netherlands
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7051928/ https://www.ncbi.nlm.nih.gov/pubmed/31418127 http://dx.doi.org/10.1007/s10565-019-09488-2 |