TCR–pMHC bond conformation controls TCR ligand discrimination

A major unanswered question is how a TCR discriminates between foreign and self-peptides presented on the APC surface. Here, we used in situ fluorescence resonance energy transfer (FRET) to measure the distances of single TCR–pMHC bonds and the conformations of individual TCR–CD3ζ receptors at the m...

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Detalles Bibliográficos
Autores principales: Sasmal, Dibyendu K., Feng, Wei, Roy, Sobhan, Leung, Peter, He, Yanran, Cai, Chufan, Cao, Guoshuai, Lian, Huada, Qin, Jian, Hui, Enfu, Schreiber, Hans, Adams, Erin J., Huang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052167/
https://www.ncbi.nlm.nih.gov/pubmed/31530899
http://dx.doi.org/10.1038/s41423-019-0273-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052167/
https://www.ncbi.nlm.nih.gov/pubmed/31530899
http://dx.doi.org/10.1038/s41423-019-0273-6

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