Cutting off the fuel supply to calcium pumps in pancreatic cancer cells: role of pyruvate kinase-M2 (PKM2)

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) has poor survival and treatment options. PDAC cells shift their metabolism towards glycolysis, which fuels the plasma membrane calcium pump (PMCA), thereby preventing Ca(2+)-dependent cell death. The ATP-generating pyruvate kinase-M2 (PKM2) is onco...

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Detalles Bibliográficos
Autores principales: James, Andrew D., Richardson, Daniel A., Oh, In-Whan, Sritangos, Pishyaporn, Attard, Thomas, Barrett, Lisa, Bruce, Jason I. E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052184/
https://www.ncbi.nlm.nih.gov/pubmed/31819190
http://dx.doi.org/10.1038/s41416-019-0675-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052184/
https://www.ncbi.nlm.nih.gov/pubmed/31819190
http://dx.doi.org/10.1038/s41416-019-0675-3

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