Clarithromycin inhibits autophagy in colorectal cancer by regulating the hERG1 potassium channel interaction with PI3K

We have studied how the macrolide antibiotic Clarithromycin (Cla) regulates autophagy, which sustains cell survival and resistance to chemotherapy in cancer. We found Cla to inhibit the growth of human colorectal cancer (CRC) cells, by modulating the autophagic flux and triggering apoptosis. The acc...

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Detalles Bibliográficos
Autores principales: Petroni, Giulia, Bagni, Giacomo, Iorio, Jessica, Duranti, Claudia, Lottini, Tiziano, Stefanini, Matteo, Kragol, Goran, Becchetti, Andrea, Arcangeli, Annarosa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052256/
https://www.ncbi.nlm.nih.gov/pubmed/32123164
http://dx.doi.org/10.1038/s41419-020-2349-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052256/
https://www.ncbi.nlm.nih.gov/pubmed/32123164
http://dx.doi.org/10.1038/s41419-020-2349-8

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