Dexmedetomidine Protects Against Lipopolysaccharide-Induced Acute Kidney Injury by Enhancing Autophagy Through Inhibition of the PI3K/AKT/mTOR Pathway

BACKGROUND: Acute kidney injury (AKI) is often secondary to sepsis. Previous studies suggest that damaged mitochondria and the inhibition of autophagy results in AKI during sepsis, but dexmedetomidine (DEX) alleviates lipopolysaccharide (LPS)-induced AKI. However, it is uncertain whether the renopro...

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Detalles Bibliográficos
Autores principales: Zhao, Yuan, Feng, Xiujing, Li, Bei, Sha, Jichen, Wang, Chaoran, Yang, Tianyuan, Cui, Hailin, Fan, Honggang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052304/
https://www.ncbi.nlm.nih.gov/pubmed/32158395
http://dx.doi.org/10.3389/fphar.2020.00128

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052304/
https://www.ncbi.nlm.nih.gov/pubmed/32158395
http://dx.doi.org/10.3389/fphar.2020.00128

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