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Molecular dynamics simulations suggest stabilizing mutations in a de novo designed α/β protein
Designing functional proteins that can withstand extreme heat is beneficial for industrial and protein therapeutic applications. Thus, elucidating the atomic-level determinants of thermostability is a major interest for rational protein design. To that end, we compared the structure and dynamics of...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052480/ https://www.ncbi.nlm.nih.gov/pubmed/32086513 http://dx.doi.org/10.1093/protein/gzaa005 |