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α-Synuclein Translocates to the Nucleus to Activate Retinoic-Acid-Dependent Gene Transcription
α-Synuclein (α-Syn) protein is implicated in the pathogenesis of Parkinson disease (PD). It is primarily cytosolic and interacts with cell membranes. α-Syn also occurs in the nucleus. Here we investigated the mechanisms involved in nuclear translocation of α-Syn. We analyzed alterations in gene expr...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052517/ https://www.ncbi.nlm.nih.gov/pubmed/32120069 http://dx.doi.org/10.1016/j.isci.2020.100910 |