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gscreend: modelling asymmetric count ratios in CRISPR screens to decrease experiment size and improve phenotype detection
Pooled CRISPR screens are a powerful tool to probe genotype-phenotype relationships at genome-wide scale. However, criteria for optimal design are missing, and it remains unclear how experimental parameters affect results. Here, we report that random decreases in gRNA abundance are more likely than...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052974/ https://www.ncbi.nlm.nih.gov/pubmed/32122365 http://dx.doi.org/10.1186/s13059-020-1939-1 |