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Modelling the effect of subcellular mutations on the migration of cells in the colorectal crypt

BACKGROUND: Many cancers arise from mutations in cells within epithelial tissues. Mutations manifesting at the subcellular level influence the structure and function of the tissue resulting in cancer. Previous work has proposed how cell level properties can lead to mutant cell invasion, but has not...

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Detalles Bibliográficos
Autores principales: Romijn, Lotte B., Almet, Axel A., Tan, Chin Wee, Osborne, James M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053074/
https://www.ncbi.nlm.nih.gov/pubmed/32126976
http://dx.doi.org/10.1186/s12859-020-3391-3