High-protein diets increase cardiovascular risk by activating macrophage mTOR to suppress mitophagy

High protein diets are commonly utilized for weight loss, yet have been reported to raise cardiovascular risk. The mechanisms underlying this risk are unknown. Here, we show that dietary protein drives atherosclerosis and lesion complexity. Protein ingestion acutely elevates amino acid levels in blo...

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Detalles Bibliográficos
Autores principales: Zhang, Xiangyu, Sergin, Ismail, Evans, Trent D., Jeong, Se-Jin, Rodriguez-Velez, Astrid, Kapoor, Divya, Chen, Sunny, Song, Eric, Holloway, Karyn B., Crowley, Jan R., Epelman, Slava, Weihl, Conrad C., Diwan, Abhinav, Fan, Daping, Mittendorfer, Bettina, Stitziel, Nathan O., Schilling, Joel D., Lodhi, Irfan J., Razani, Babak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053091/
https://www.ncbi.nlm.nih.gov/pubmed/32128508
http://dx.doi.org/10.1038/s42255-019-0162-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053091/
https://www.ncbi.nlm.nih.gov/pubmed/32128508
http://dx.doi.org/10.1038/s42255-019-0162-4

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