Optogenetic Control of Spine-Head JNK Reveals a Role in Dendritic Spine Regression

In this study, we use an optogenetic inhibitor of c-Jun NH(2)-terminal kinase (JNK) in dendritic spine sub-compartments of rat hippocampal neurons. We show that JNK inhibition exerts rapid (within seconds) reorganization of actin in the spine-head. Using real-time Förster resonance energy transfer (...

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Detalles Bibliográficos
Autores principales: Hollos, Patrik, John, Jismi M., Lehtonen, Jukka V., Coffey, Eleanor T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2020
Materias:
New Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053173/
https://www.ncbi.nlm.nih.gov/pubmed/31937523
http://dx.doi.org/10.1523/ENEURO.0303-19.2019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053173/
https://www.ncbi.nlm.nih.gov/pubmed/31937523
http://dx.doi.org/10.1523/ENEURO.0303-19.2019

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