MANF Ablation Causes Prolonged Activation of the UPR without Neurodegeneration in the Mouse Midbrain Dopamine System

Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an endoplasmic reticulum (ER) localized protein that regulates ER homeostasis and unfolded protein response (UPR). The biology of endogenous MANF in the mammalian brain is unknown and therefore we studied the brain phenotype of MANF-defic...

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Detalles Bibliográficos
Autores principales: Pakarinen, Emmi, Danilova, Tatiana, Võikar, Vootele, Chmielarz, Piotr, Piepponen, Petteri, Airavaara, Mikko, Saarma, Mart, Lindahl, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2020
Materias:
Research Article: New Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053174/
https://www.ncbi.nlm.nih.gov/pubmed/32005751
http://dx.doi.org/10.1523/ENEURO.0477-19.2019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053174/
https://www.ncbi.nlm.nih.gov/pubmed/32005751
http://dx.doi.org/10.1523/ENEURO.0477-19.2019

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