Allele-specific genome targeting in the development of precision medicine

The CRISPR-based genome editing holds immense potential to fix disease-causing mutations, however, must also handle substantial natural genetic variations between individuals. Previous studies have shown that mismatches between the single guide RNA (sgRNA) and genomic DNA may negatively impact sgRNA...

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Detalles Bibliográficos
Autores principales: Wu, Junjiao, Tang, Beisha, Tang, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053192/
https://www.ncbi.nlm.nih.gov/pubmed/32194858
http://dx.doi.org/10.7150/thno.43298

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053192/
https://www.ncbi.nlm.nih.gov/pubmed/32194858
http://dx.doi.org/10.7150/thno.43298

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