The potential of combined mutation sequencing of plasma circulating cell‐free DNA and matched white blood cells for treatment response prediction

Highly sensitive mutation detection methods enable the application of circulating cell‐free DNA for molecular tumor profiling. Recent studies revealed that sequencing artifacts, germline variants, and clonal hematopoiesis confound the interpretation of sequencing results and complicate subsequent tr...

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Detalles Bibliográficos
Autores principales: van der Leest, Paul, Schuuring, Ed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053232/
https://www.ncbi.nlm.nih.gov/pubmed/32017376
http://dx.doi.org/10.1002/1878-0261.12646
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author van der Leest, Paul
Schuuring, Ed
author_facet van der Leest, Paul
Schuuring, Ed
author_sort van der Leest, Paul
collection PubMed
description Highly sensitive mutation detection methods enable the application of circulating cell‐free DNA for molecular tumor profiling. Recent studies revealed that sequencing artifacts, germline variants, and clonal hematopoiesis confound the interpretation of sequencing results and complicate subsequent treatment decision making and disease monitoring. Parallel sequencing of matched white blood cells promises to overcome these issues and enables appropriate variant calling. Comment on: https://doi.org/10.1002/1878-0261.12617 [Image: see text]
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spelling pubmed-70532322020-03-09 The potential of combined mutation sequencing of plasma circulating cell‐free DNA and matched white blood cells for treatment response prediction van der Leest, Paul Schuuring, Ed Mol Oncol Commentary Highly sensitive mutation detection methods enable the application of circulating cell‐free DNA for molecular tumor profiling. Recent studies revealed that sequencing artifacts, germline variants, and clonal hematopoiesis confound the interpretation of sequencing results and complicate subsequent treatment decision making and disease monitoring. Parallel sequencing of matched white blood cells promises to overcome these issues and enables appropriate variant calling. Comment on: https://doi.org/10.1002/1878-0261.12617 [Image: see text] John Wiley and Sons Inc. 2020-02-23 2020-03 /pmc/articles/PMC7053232/ /pubmed/32017376 http://dx.doi.org/10.1002/1878-0261.12646 Text en © 2020 The Authors. Published by FEBS Press and John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
van der Leest, Paul
Schuuring, Ed
The potential of combined mutation sequencing of plasma circulating cell‐free DNA and matched white blood cells for treatment response prediction
title The potential of combined mutation sequencing of plasma circulating cell‐free DNA and matched white blood cells for treatment response prediction
title_full The potential of combined mutation sequencing of plasma circulating cell‐free DNA and matched white blood cells for treatment response prediction
title_fullStr The potential of combined mutation sequencing of plasma circulating cell‐free DNA and matched white blood cells for treatment response prediction
title_full_unstemmed The potential of combined mutation sequencing of plasma circulating cell‐free DNA and matched white blood cells for treatment response prediction
title_short The potential of combined mutation sequencing of plasma circulating cell‐free DNA and matched white blood cells for treatment response prediction
title_sort potential of combined mutation sequencing of plasma circulating cell‐free dna and matched white blood cells for treatment response prediction
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053232/
https://www.ncbi.nlm.nih.gov/pubmed/32017376
http://dx.doi.org/10.1002/1878-0261.12646
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